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The structure of liraglutide (a structurally distinct analog of GLP-1RA) was found to be unfavorable for co-formulation with SNAC on account of its stronger membrane-binding properties, which reduced transcellular passage, as well as its greater tendency to oligomerize, which countered the monomerizing effects of SNAC [56]

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However, the review notes that not all preclinical results have been uniformly positive

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At that point the trial randomized them into three groups for the next fifty-two weeks of double-blind treatment